You can erase these if you haven't had errors related to upgrading Windows to a new version. These are safe to delete in most cases, but you should keep them for troubleshooting if you run into update-related issues.
However, the following several options are low-hanging fruit (make sure to select Clean up system files first to see them all): This isn't a full guide to the Disk Cleanup tool, so we're not going to look at every option it offers.
